Showing posts with label Educational - Diseases. Show all posts
Showing posts with label Educational - Diseases. Show all posts

Tuesday, August 10, 2010

The BIG "R"!!!

  That's Rejection... (not Ricki) Though neither one of us are to be feared, I'm not to be taken as serious as the big R. heheee... 
Why am I even mentioning the R word, bad ju-ju!!! (nope, I don't believe in that... just ask my surgeon, who after the 5th or 20th time of me mentioning my previous DIC episode before my transplant, finally looked over at me and said straight out... "Shhh, don't mention that word again, we don't talk about that in the hospital" ...Like I was the CRAZY one) Anywho, yesterday was my clinic day, and I knew it was going to be a long one because I needed my magnesium fix. The last few weeks I have been getting infusions twice a week, but this was the first time I had gone 7 whole days without it... and I was feeling it. By Sunday night, I felt like I could pass out at any second from exhaustion. However, when they did my lab work, they also found that my ALT and AST levels had slightly raised, which can mean rejection...
So, what's the plan? More hospitalization? Another liver transplant?? Possibly, but not likely... Most likely, they will just need to change up my anti-rejection meds... Ok, not "just" but they have been doing this for years now, and have gotten pretty good at it, so I trust completely that they know what they are doing and will get my body behaving nicely to Sally again. 
So last night, my nurse called me back and told me to raise my Prograf .5mg and come back on Wednesday morning to see if the counts have gone down any. If not, then... well we will take it from there, but most likely I'll be getting more USC tacos (and you know how I likes me some tacos) ...I'll keep you posted.
Below is some information on rejection (for us liver patients, different organs have different signs). It is the word that any of us transplant patients dread to hear, for fear of losing our precious gift. However, it is more common then I thought, and if caught on time, can be treated successfully. Whoo hoo!!

Rejection
The body's immune system protects a person from infection by recognizing certain foreign substances, such as bacteria and viruses, and destroying them. Unfortunately, the immune system recognizes a new liver as a foreign substance also. Rejection is an attempt by the immune system to attack the transplanted liver and destroy it. To prevent rejection from occurring, a recovering patient must take immunosuppressive medications, as prescribed, for the rest of his life.
In spite of all precautions, rejection episodes can occur. Up to 75% of all liver-transplant recipients will have at least one rejection episode, even though these people are taking immunosuppressants. The first episode often occurs within 2 months of surgery. Rejections are usually controlled by changing the dosages of immunosuppressive medications or temporarily adding a new one.
If detected early, most rejection episodes can be treated successfully. A patient should be alert to the signs and symptoms of rejection and inform his transplant team promptly if he has the following.
  • fatigue
  • fever
  • abdominal pain or tenderness
  • dark yellow/orange urine
  • clay-colored stools
A patient may not have any symptoms, but his liver-function tests may be abnormal, suggesting that rejection is occurring. This is why maintaining a strict appointment schedule with the transplant team is critical. When rejection is suspected, it is usually confirmed by a liver biopsy. Based on the results, the transplant team will decide the best treatment. As with all transplant patients, a patient may have biopsies at regular intervals to monitor his liver function.

Friday, June 4, 2010

Hepatic Encephalopathy (and a hodgepodge of stuff.)

Being that I have been M.I.A. these past few months I thought I would explain to you the reason. Yes most of it is from a symptom of my cirrhosis, Hepatic Encephalopathy... Not only has it caused me to be slightly O.C.D. (I do things over and over again, and check time repeatedly because I don't want to forget something) and now I can't even be all "Martha Stewart" with home projects because of this twitching and low attention span. hehe... I know, the things I whine about)  We have also had a few real issues, kinks, and losses to deal with. The toughest, the loss of my Papa Earl this month. He was 80 years old. Rest in peace papa!! We have also had a few financial scares (who hasn't) my husband has pretty much lost his job, but God has provided. Jason has been doing free-lance work (lets pray the company does well, and likes Jason enough to hire him.) AND (by the grace of God, and the amazing owner of Rezn8) We have been able to keep our insurance, at least for now. We have such amazing family and friends that not only have sent their prayers and good vibes, but also donations! Donations of time, Harley rides (hehe), and money from $1.00 to hundreds of dollars, and again, just when I think we cannot be any more blessed... The biggest gift anyone can give, a second chance at life, my liver sliver giver (sorry, I can't resist) Jason's cousin, Nancy. << Trust me when I say, this is HUGE, and doesn't happen often for people... Whoa, whoa, Nelly... Reign 'er in there Ricki... tehehe, this post was supposed to be about Hepatic Encephalopathy, I have found some interesting articles on conflicting research on protein restrictions (I myself have come to the conclusion... in my expert opinion that doctors mislead us by saying low protein, but what they REALLY mean to say is low animal proteins, stick with mostly vegetarian type proteins... and lots of carbs. Low protein will lead to malnourishment and no energy, trust me) ...Please correct me if you disagree. Also, I have found some interesting stuff on vitamins and BCAA's (Branch-chain amino acids), L-carnitine, rifaximin... and have come to the conclusion that Lactulose is probably not the most effective treatment for H.E., rifaximin is probably better (even though Lactulose is what I use) I also personally take Zinc which has been shown to improve HE (I think B-12 has also helped with the mental fog for me... but that is just me - could just be the extra energy of B-12.) And I really don't see any negative effects of these or even the BCAA's many recommend. I hope I am not leaving anything out... Of course the obvious, as with any toxin, the goal is to get it out of the body, so to add to it by taking any drugs whether over the counter, prescribed, or not... ANYTHING that is not absolutely necessary (and obviously alcohol will intensify the effects of HE) should be avoided! Ok, I think that is all I have to say right now about that... I know I should cite where I found all this golden information... but I'm tired, and like I said, I do not claim to be a doctor, but here is one great site that explains it much better then me, the rest you will just have to take my word for... muwahahaha. (Click here to learn more about my newest nemesis... So bad it needs no other name then H.E.) hehehehe... I'm not going to even try to blame my cheesiness on it though.

Sunday, November 15, 2009

What's goin' on in there?

The other day, my mom said that I seemed more clear - alert. I agreed, I had already given River a bath, started the dishes, and when she mentioned it, I was wiping down the trash can with a Clorox cloth before I put the bag in. It was what I was doing right then that made me smile, because I was on a roll. I had taken out the trash, automatically cleaned the can and put a bag in.... 3 steps in a row that I hadn't completed so easily in months. These are the days I live for! BIG deal guys!!! - my head didn't even hurt with confusion. Lately, I have had to stare at each item for a second and then it clicks...What's this? Garbage bag. Where does it go? Garbage bag go herrre.
So below is my diagnosis along with MY symptoms (I took out the ones I don't have - please see the ALF website for a complete list) I have completed ultrasounds, MRI's, massive lab work, and physical examination for my diagnosis from multiple doctors now.

Ricki's Diagnosis and Treatment:
  • Decompensated cirrhosis - End stage liver disease: means that the severe scarring of the liver has damaged and disrupted essential body functions. -- The reason? I was born with the Hepatitis C virus, I have high blood/iron levels, mixed together with shear luck of the draw! MELD Score - 15. Treatment options - Liver Transplant by either living or deceased donor with a blood type of A or O.

Ricki's whine fest.
  • Fatigue and loss of energy
  • Loss of appetite and weight loss (Kinda cool -- at first)
  • Nausea / abdominal pain / Vomiting (This is what started it all last August - DAILY VOMITING)
  • Spider angiomas - These are pinhead-sized red spots from which tiny blood vessels radiate. (I just recently, and very happily found out that these do go away, it just takes many months... Luckily when the ones in my eyes pop, it only takes a few days to go away, don't worry, I have found that not bending at the waist reduces the pressure that causes those to burst...Yaeh!)
  • Ascites - Fluid buildup in the legs and feet (edema) and in the abdomen (ascites). Due to portal hypertension. (This so far has proven to be my greatest nemesis!)
  • Hepatic Encephalopathy (Causes my confusion, irritation, lethargy, muscle ticks...)
  • Jaundice. This yellowish cast to the skin and eyes occurs because the liver cannot process bilirubin for elimination from the body. (I prefer to call this color - tanned)
  • Itching. Itching (pruritus) develops from buildup of bile products. (This just sucks)
  • Easy bruising (This with the extreme tan look is what gives me the nickname BB...Bruised Banana)
  • Excessive bleeding (This one scares my momma - even if it is just a nose bleed)
  • Thinning skin (making it impossible to wax) and Thinning Hair :(
  • Wasting (Malnutrition - This is what I find gives me that "models bone structure")
Ok, so what have we learned? One. Cirrhosis sucks. Two. Cirrhosis is broken down in two stages - Compensated and then Decompensated (People can live many years without even knowing they have cirrhosis) and Three. BE YOUR OWN ADVOCATE! Many people can slow, stop, and even reverse damage done to the liver! Transplant is the last option. I, for one, do not want to receive a liver ahead of anyone else suffering in need - I don't want to be part of the problem... the shortage.

Sunday, September 6, 2009

Hepatocellular Carcinoma

Hepatocellular carcinoma

MedlinePlus
Hepatocellular carcinoma

Hepatocellular carcinoma is cancer of the liver.

  • Abdominal pain or tenderness, especially in the upper-right part
  • Easy bruising or bleeding
  • Enlarged abdomen
  • Yellow skin and eyes (jaundice)

Aggressive surgery or a liver transplant may successfully treat small or slow-growing tumors if they are diagnosed early. However, few patients are diagnosed early.

Chemotherapy and radiation treatments are not usually effective. However, they may be used to shrink large tumors so that surgery has a greater chance of success.

Sorafenib toslate (Nexavar), a medicine that blocks tumor growth, is now available for patients with liver tumors.

Hepatocellular carcinoma accounts for 80 - 90% of all liver cancers. This type of cancer occurs more often in men than women. It is usually seen in people ages 50 - 60.

The disease is more common in parts of Africa and Asia than in North or South America and Europe.

Hepatocellular carcinoma is not the same as metastatic liver cancer, which starts in another organ (breast or colon) and spreads to the liver.

The cause of liver cancer is usually scarring of the liver (cirrhosis). Cirrhosis may be caused by:

  • Alcohol abuse (the most common cause in the U.S.)
  • Certain autoimmune diseases of the liver
  • Diseases that cause long-term swelling and irritation (chronic inflammation) of the liver
  • Hepatitis B and C
  • Too much iron in the body (hemochromatosis)

Patients with hepatitis B or C are at risk for liver cancer, even if they do not have cirrhosis.

Physical examination may show an enlarged, tender liver.

Tests include:

  • Abdominal CT scan
  • Liver biopsy
  • Liver enzymes (liver function tests)
  • Liver scan
  • Serum alpha fetoprotein

Some high-risk patients may get periodic blood tests and ultrasounds to see if tumors are developing.

The usual outcome is poor, because only 10 - 20% of hepatocellular carcinomas can be removed completely using surgery.

If the cancer cannot be completely removed, the disease is usually deadly within 3 - 6 months. However, survival can vary, and occasionally people will survive much longer than 6 months.

Preventing and treating viral hepatitis may help reduce your risk. Childhood vaccination against hepatitis B may reduce the risk of liver cancer in the future.

Avoid drinking excessive amounts of alcohol. Certain patients may benefit from hemochromatosis screening.

  • Gastrointestinal bleeding
  • Liver failure
  • Spread (metastasis) of the carcinoma

Call your health care provider if you develop persistent abdominal pain, especially if you have a history of any liver disease.

Monday, August 24, 2009

Cirrhosis and Salt (a.k.a. my newest nemesis)

Let me say that since I have started on my diuretics and reduced my salt to 2000mg, I no longer vomit every single day, I can breathe and walk better, and I don't look 8 months pregnant. I have lost over 20lbs since starting this regiment last month and have not woken up with my face so swollen that I couldn't see properly....My major culprits were canned veggies and beans, soy sauce, processed lunch meats and cheeses. Doctors thought that since I am young, I must be healthy...They put me on anti-depressants because they assumed it was a nervous stomach. Months went by and I was still sick. A second opinion resulted in an ultrasound, which showed a moderate amount of fluid build up in the abdomen....which is how our journey here began. Even if you do not have liver damage, I just thought the following article was very interesting, however if you do...please read this-- I know that my doctors in the past did NOT stress the importance of salt restriction!

Important Facts About Salt and Cirrhosis

Upon being diagnosed with cirrhosis, physicians typically advise their patients to completely avoid, or significantly restrict, sodium intake. Learn why eliminating foods with salt from your diet is absolutely necessary if you’re living with cirrhosis – and find out some helpful hints on how to minimize salt intake.

by Nicole Cutler, L.Ac.

When liver disease progresses it can lead to cirrhosis, the permanent hardening, shrinking, scarring and reduced functioning of the liver. Upon being diagnosed with cirrhosis, physicians typically advise their patients to completely avoid, or significantly restrict, sodium intake. With all of the lifestyle changes demanded of a person with advancing liver disease, avoiding sodium can seem like yet another restriction on your culinary freedom. However, passing on foods with salt is more than just a casual recommendation – the pathology of cirrhosis makes it a necessity.

Osmosis
Consuming salt fosters water retention. When in the blood supply, salt draws water out of the surrounding cells into the blood via osmosis. Remembering back to high school chemistry, osmosis is the tendency of concentrations across semi-permeable barriers to equalize. This is easily illustrated when salted water flows from an area of low salt concentration to an area of high salt concentration until both are of the same concentration. Because the body’s cells work best when a constant state is maintained, we are hardwired to keep mineral concentrations (such as salt) balanced. Therefore, the more salt in a person’s diet, the more fluid the body retains in an effort to dilute the salt.

Related Cirrhosis Pathology
When liver function is reduced, several biological events further caution against eating salt. The following physiological processes render a person with cirrhosis much more vulnerable to salt ingestion:

· Blood Pressure – As cirrhosis progressively scars the liver, its ability to effectively filter blood is reduced. This results in a reduced volume of blood, which lowers blood pressure. When blood pressure is low, signals are sent to the kidneys causing a release of chemicals for retaining salt and fluids.

· Albumin – The liver produces the protein albumin, which is responsible for holding fluid inside the blood vessels. Scarring of the liver causes blood albumin levels to fall, resulting in fluids seeping out of the leg and abdomen tissues.

· Portal Hypertension – When liver scarring causes a backup of blood, portal hypertension develops, elevating pressure in the vasculature coursing through the liver. Following the principles of osmosis, some of the fluid inside the highly pressurized portal vein leaks out to prevent the blood vessel from bursting.

The fluid retention typical of cirrhosis is typically found in two locations:

1. Edema – Due to gravity’s pressure, excess fluid accumulates in the tissue beneath the skin of the ankles and legs. Called edema, this swelling is typically worse at the end of the day, after a person has been on his or her feet all day long.

2. Ascites – As more salt and water are retained and liver function decreases, fluid accumulates in the abdomen. Increased abdominal fluid causes the kidneys to retain even more water, because they think the body is dehydrated. Known as ascites, swelling of the abdomen is a telltale sign of cirrhosis.

Why Ascites Is Unwanted
Aside from expanding girth around the midsection, ascites can cause the following medical complications:

· Abdominal Pain, Discomfort and Difficulty Breathing – When too much fluid accumulates in the abdominal cavity, the ability to eat, ambulate and perform activities of daily living can be severely limited.

· Infection – Known as spontaneous bacterial peritonitis, ascites can cause infection marked by abdominal pain, tenderness, fever or nausea. Without prompt medical intervention, spontaneous bacterial peritonitis can cause kidney failure, severe blood infection and mental confusion.

· Hernia – Elevated intra-abdominal pressure from ascites can lead to the development of umbilical and inguinal hernias. Typically manifesting with abdominal discomfort, pain or an abdominal bulge, a surgical repair may be necessary.

· Hepatic Hydrothorax – Ascites can cause fluid to permeate the chest. Called hepatic hydrothorax, abdominal fluid fills the lung cavities causing severe breathing difficulties. Furthermore, a buildup of fluid in the lungs can lead to heart failure.

How to Minimize Salt Intake
Since fluid accumulation associated with cirrhosis can be severe, diet is the first and most important intervention. Limiting dietary sodium helps prevent retaining extra fluid. Physicians typically advise limiting salt intake to 4-5 grams per day (2,000 mg of sodium) or less. Since it can be difficult to determine the salt content of various foods, it is generally recommended that someone with ascites see a nutritionist for advice about various foods to avoid.

For those who add table salt to food, a salt substitute may be ideal. However, choose one without potassium because blood potassium levels can increase with certain medications used to treat ascites. It is important to discuss with your doctor or dietician the salt substitute you are planning to use.

If you don’t already, start reading food labels to decipher their sodium content. Limit packaged, processed and restaurant foods, which are typically high in sodium. Cook with less sodium by choosing fresh or frozen foods, rinse canned vegetables and avoid these high sodium flavorings: soy sauce, steak sauce, onion salt, garlic salt, mustard and ketchup. Some hidden forms of salt to avoid include monosodium glutamate, sodium citrate, sodium alginate, sodium hydroxide and sodium phosphate.

By making a conscious effort to minimize the salt in your diet, you are taking huge steps to reduce the toll fluid retention takes on your body. People who have cirrhosis will feel much better when fluid buildup in their abdomen and legs abate. For people with advanced liver disease, skipping salt is as important as medications prescribed by your physician. With patience, experimentation and a sense of adventure, you can break free of sodium’s culinary limits by discovering the abundance of tasty, salt-free meals. So resist the increasing health problems caused by cirrhosis by squeezing some fresh lemon over your broccoli and tossing the salt shaker in the trash.

References:

Cardenas, Andres, Arroyo, V., Mechanisms of water and sodium retention in cirrhosis and the pathogenesis of ascites, Clinical Endocrinology and Metabolism, Vol.17, 2003.

www.aafp.org, Preventive Strategies in Chronic Liver Disease, Thomas R. Riley III, MD, MS, Ahsan M. Bhatti, MD, American Academy of Family Physicians, 2007.

www.cvphysiology.com, Tissue Edema and General Principles of Transcapillary Fluid Exchange, Richard E. Klabunde, 2007.

www.gi.org, Ascites: A Common Problem in People with Cirrhosis, Raj Vuppalanchi, MD, Naga Chalasani, MD, American College of Gastroenterology, 2007.

www.gicare.com, Cirrhosis, Jackson Siegelbaum Gastroenterology, 2007.

www.gut.bmj.com, Sodium in Preascitic Cirrhosis: Please Pass the Salt, J. Claria, J. Rodes, Gut, December 2001.

www.health.yahoo.com, Eating a Low-Sodium Diet When you Have Cirrhosis, Shannon Erstad, MBA/MPH, Healthwise, Inc., 2007.

www.hepatitis.va.gov, Eating Tips for People with Cirrhosis, United States Department of Veteran Affairs, 2007.

www.medicinenet.com, Primary Biliary Cirrhosis, MedicineNet Inc., 2007.

Saturday, August 22, 2009

Liver Disease Symptom Quiz

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RICKI's Liver Disease Symptom Quiz Score Report

Total number of questions: 12

Total number of correct answers: 12

Your QuizMoz Score: 100%

Average Score for this quiz: 59.5%

Number of people taken this quiz: 120

Maximum score for this quiz: 100%

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